MORAb-009 induces ADCC. (A) OVCAR-3 cells were used as target cells and reacted with 10 µg/mL of MORAb-009 or control IgG in the presence of human PBMCs at a ratio of 1:25. ADCC activity was measured by LDH release and only noted with MORAb-009 treatment. (B) Same as in A, whereby target cells (Panc 3.27) express low or no mesothelin. (C) NCI-H226 cells were used as target cells and reacted with 10 µg/mL of MORAb-009 or control IgG in the presence of human PBMCs at different ratios. ADCC activity was measured by ⁵¹Cr release and only noted with MORAb-009 treatment. (D) Same as in C, whereby target cells (Panc 10.05) express no or low levels of mesothelin.