Tyrosinase is conserved from dog to mouse to man. Sequence comparison of tyrosinase from dog, mouse, and human shows a high degree of homology at the amino acid level. The calculated sequence identity by Vector NTI between canine tyrosinase and that of mouse and human is 84.4% and 87.5%, respectively, indicating evolutionary conservation of this protein. Dark gray highlights identical residues and light gray highlights conservative amino acid changes.