Neo-adjuvant TIM-ILP for soft tissue sarcoma (I). The woman, 42, had a grade 3, stage III, malignant fibrohistiocytoma of the left calf which was in contact with neurovascular elements. She had progressed on two courses of systemic ifosfamide/doxorubicine. Left: MRI before TIM-ILP. Right: MRI 3 months after TIM-ILP. Massive necrosis except for a 5% area (arrow) that was still containing live sarcoma cells in the surgical specimen.