Thick capsule formation after TIM-ILP. Shown are two cases of tumour remnants (surgical samples). (A) Malignant fibrohistiocytoma of the left calf (refer to the legends of Figures 8 and 9) removed 3 months after TIM-ILP. (B) Extraosseous osteosarcoma of the right thigh (refer to the legend of Figure 12) removed two months after TM-ILP. In both cases, there was slight tumour shrinkage, but more than 60% histological necrosis. Tumour remnants were surrounded by a thick capsule (arrow). Histological appearance of a tumour capsule after TIM-ILP: (C) 30 days after perfusion, intense inflammation with loose capsule; (D) 3 months after perfusion, the capsule is thick with abundant collagen bundles and oedema.