Efficacy of TIM-ILP on proximal melanoma limb metastases. The patient, an 83-year old woman, presented with numerous in-transit melanoma metastases extending to the proximal aspect of the left thigh. Upper left: before TIM-ILP. Lower left: day 1 after TIM-ILP; a general tumour collapse can be seen. Upper right: complete response was obtained on day 21. Lower right: 10 months after TIM-ILP, recurrent small amelanotic metastases. Black spots were tattoos from previously regressed metastases. Work-up demonstrated lung and liver metastases and the patient died from her disease 12 months after TIM-ILP.