Efficacy of TIM-ILP on bulky melanoma metastases. The patient, a 70-year old woman with bulky in-transit melanoma metastases on a lower limb, had been considered for hip exarticulation in other hospitals. She received one TIM-ILP through the iliac vessels. From left to right: presentation on the day of TIM-ILP; on day 14, extensive necrosis, and, on day 44, complete response. The patient enjoyed CR for 9 months and thereafter developed extensive visceral metastases and died from disease.