Recurrent osteosarcoma treated by neo-adjuvant TM-ILP. The patient is a 75 year old male with extraosseous osteosarcoma of the external aspect of the left thigh that had been widely resected 1 year before, with marginal osteotomy and osteosynthesis. Recurrent sarcoma developed in the internal aspect of the thigh. TM-ILP produced tumour shrinkage and marginal resection showed 65% histological necrosis.