Neo-adjuvant TIM-ILP for soft tissue sarcoma (IV). Shown are comparative MRIs of the left thigh before and on day 30 after TIM-ILP. Before treatment, the sarcoma was invading the whole quadriceps and was surrounding the femur shaft (left). After treatment, 60% of tumour was necrotic and the gadolinium positive area was restricted to the rectus anterior muscle. The tumour remnants were removed and closure was performed with plastic, reconstructive surgery. The patient remained well until the tenth month after ILP when she developed lung metastases and groin recurrence. Systemic chemotherapy was inefficient and she died on the twelfth month after TIM-ILP.