| 
Rejection
of IFNGR1 deficient RAD.gR.28 sarcomas following reconstitution
of IFN-gamma responsiveness. An MCA sarcoma cell line (RAD.gR.28)
from an IFNGR1-/- mouse was transduced either with empty retrovirus
(control), a functionally inactive IFNGR1 C-terminal truncation
mutant (IFNGR1deltaIC) or wild type IFNGR1. After isolation of
homogeneous transduced cell populations, groups of 5 wild type,
genetically matched mice were injected with 1 x 106
of each cell type. Tumor growth was quantitated by daily measurement
of tumor size [adapted from (54)]. |
