Increased formation of carcinogen-induced sarcomas in immunocompromised mice. Large groups of sex- and age-matched wild type 129 strain mice or 129 strain mice with targeted disruption of the genes for RAG2, IFNGR1 (the ligand binding subunit of the IFN-gamma receptor), STAT1 (the transcription factor critical for IFN-gamma- and IFN-alpha/beta-receptor signaling), or RAG2 plus STAT1, were treated with a 100 µg dose of the chemical carcinogen 3’-methylcholanthrene and tumor formation was followed over time. The final tumor incidences of each group is shown at 160 days [adapted from (49)].