| 
FACS®
analyses of the peripheral blood of patients after receiving KM871
exhibit similar profiles. (A) Proportion of neutrophils, macrophages,
and lymphocytes expressed as the mean ± SD percentage of
total white blood cells. Total lymphocytes were not determined
in samples collected before and after 1 mg/m2, nor
before and after 5 mg/m2 dose levels. (B) Proportion
of lymphocyte subpopulations expressed as the mean ± SD
percentage of total lymphocytes. Lightly dotted bars indicate
a 1 mg/m2 dose before the first infusion; heavily dotted
bars indicate 5 mg/m2 before the first infusion; cream
bars indicate 10 mg/m2 before the first infusion; black
bars indicate 20 mg/m2 before the first infusion; open
bars indicate 1 mg/m2 before the final infusion; (\\)
indicates 5 mg/m2 before the final infusion; (//) indicates
10 mg/m2 before the final infusion; squares indicate
20 mg/m2 before the final infusion; and hatchmarks
indicate 40 mg/m2 before the final infusion. |