Toxicity

Cohort 1
(n=9)

Cohort 2
(n=10)

Cohort 3
(n=8)

CTC Grade

1/2

3/4

1/2

3/4

1/2

3/4

Lethargy

4

1

6

2

6

-

FL injection site reaction

6

-

4

-

6

-

Monocytosis

6

-

4

-

6

-

URTI symptoms ^a

4

-

6

-

3

-

Fever

3

-

6

-

2

-

Headache

4

-

2

-

4

-

Anemia

3

-

3

-

2

-

Nausea or vomiting

2

-

3

-

2

-

Thrombocytopenia

2

-

2

-

3

-

Arthralgias

2

-

1

-

3

-

Pain - abdominal, NOS ^b

1

-

3

-

2

-

Pain - musculoskeletal

1

-

2

1

2

-

Cough

2

-

2

-

1

-

Flu-like illness

1

-

2

-

2

-

Lymphopenia

3

-

2

-

-

-

Myalgias

2

-

3

-

-

-

Peptide injection site reaction

-

-

1

-

4

-

Diarrhea

2

-

1

-

1

-

Eosinophilia

1

-

2

-

1

-

Lymphadenopathy

2

-

1

-

1

-

Sweats

-

-

3

-

1

-

Anorexia

-

-

3

-

-

-

Old scar inflammation

1

-

2

-

-

-

Skin rash

-

-

1

-

2

-

Thrombocytosis

-

-

2

-

1

-