RNAi effectively limits cellular proliferation in a dose-dependent manner. Columns corresponds to treatment groups, with the mean OD values for MTT analysis plotted on the y-axis and the bars corresponding to the standard error of the mean. (A) Cells treated for 16.5 hr with varying concentrations of IL-10 RNAi (RNAi) or scrambled IL-10 dsRNA (dsScr) (0.2-2.0 µM): Gray bar, 0.2 µM ; horizontal stripe, 0.5 µM; diamond bar, 1.0 µM; hatched bar, 2.0 µM. Error bars are the SEM of triplicate results. Asterisks indicate P < 0.05 for a Student's t-test comparing dsScr to RNAi. (B) Cells treated for 48 hr with 2 µM RNAi or dsScr. Error bars are the SEM of triplicate results. Asterisks indicate P < 0.05 for a Student's t-test comparing dsScr to RNAi.