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Clustering
HERV proviruses according to their expression patterns. All
EST sequences matched by the HERV-K family were aligned to all
HERV proviruses present in the query set (31 HERV-K proviruses
and 1 representative member for each of the HERV-H, W and E family).
Alignment scores were normalized to obtain bit scores. A color-code
ranging from red (low) to white (high) was used to represent bit
scores (lower panel). Bit scores lower than the threshold of 36
are represented in black. HERV proviruses were clustered, using
average-linkage agglomerative hierarchical clustering, based on
the binary distances between pairs of proviral sequences (upper
panel).
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