|
Cutaneous
reactions to influenza matrix peptide vaccinationa.
|
IL-12
Dose
(ng/kg)
|
Administration
Route
|
Patient
|
Study
Day
|
Response
|
|
3
|
10
|
17
|
24
|
59
|
|
0
|
i.v.
|
1
|
(+)
|
(+)
|
+
|
+
|
+
|
Y
|
|
2
|
-
|
-
|
-
|
-
|
M
|
N
|
|
3
|
+
|
(+)
|
+
|
(+)
|
NE
|
N
|
|
s.c.
|
4
|
+
|
+
|
-
|
NE
|
NE
|
NE
|
|
5
|
+
|
++
|
-
|
+
|
+
|
N
|
|
6
|
+
|
+
|
+
|
+
|
+
|
N
|
|
7
|
+
|
+
|
+
|
++
|
NE
|
N
|
|
10
|
i.v.
|
8
|
-
|
-
|
(+)
|
-
|
NE
|
N
|
|
9
|
+
|
+
|
(+)
|
(+)
|
NE
|
N
|
|
10
|
-
|
(+)
|
-
|
-
|
NE
|
N
|
|
s.c.
|
11
|
-
|
-
|
-
|
NE
|
NE
|
NE
|
|
12
|
-
|
-
|
+
|
NE
|
NE
|
NE
|
|
13
|
-
|
(+)
|
+
|
+
|
+
|
Y
|
|
14
|
-
|
(+)
|
+
|
+
|
+
|
Y
|
|
15
|
+
|
++
|
+
|
(+)
|
+
|
N
|
|
16
|
+
|
-
|
-
|
-
|
+
|
N
|
|
30
|
i.v.
|
17
|
(+)
|
-
|
-
|
(+)
|
-
|
N
|
|
18
|
-
|
(+)
|
-
|
(+)
|
NE
|
N
|
|
19
|
-
|
-
|
M
|
-
|
(+)
|
N
|
|
s.c.
|
20
|
+
|
+
|
(+)
|
+
|
+
|
N
|
|
21
|
-
|
+
|
+
|
+
|
+
|
Y
|
|
22
|
+
|
+
|
+
|
+
|
-
|
N
|
|
100
|
i.v.
|
23
|
(+)
|
-
|
-
|
-
|
(+)
|
N
|
|
24
|
+
|
-
|
+
|
+
|
NE
|
N
|
|
25
|
-
|
-
|
-
|
-
|
NE
|
N
|
|
s.c.
|
26
|
+
|
+
|
+
|
+
|
NE
|
N
|
|
27
|
+
|
+
|
(+)
|
+
|
NE
|
N
|
|
28
|
(+)
|
-
|
(+)
|
+
|
NE
|
N
|
aCutaneous
reaction scoring system: -, <4 mm diameter; (+), 4-8 mm diameter;
+, >8 mm diameter; ++, >8 mm diameter plus epidermal necrosis.
Missing data was counted as "-". Abbreviations: M, missing
data; NE, not evaluable.
|
