IL-12 Dose (ng/kg)

0

10

30

100

Administration Route
(number of subjects)

s.c.
(4)

i.v.
(3)

s.c.
(6)

i.v.
(3)

s.c.
(3)

i.v.
(3)

s.c.
(3)

i.v.
(3)

Event

Toxicity Grade^a

Number of Patients Exhibiting Event

Fever

less than or equal to 2

-

-

2

-

-

3

-

3

3

-

-

-

-

-

-

-

-

Lethargy

less than or equal to 2

-

3

-

3

-

3

1

1

3

-

-

-

-

-

-

-

-

Nausea or vomiting

less than or equal to 2

-

3

-

1

1

2

3

-

3

-

-

-

-

-

1

-

-

Pain, including tumor pain

less than or equal to 2

1

3

-

-

1

3

2

1

3

-

-

-

-

-

-

-

1

Headache

less than or equal to 2

-

2

-

1

-

3

-

1

3

-

-

-

-

-

-

-

-