Systemic injection of anti-CEA-H-2K^b/ova conjugate inhibits tumor growth in OT-1 transgenic mice. Kinetics of MC38-CEA+ syngeneic colon carcinoma tumor growth during treatment with the conjugate (filled symbols) or the control anti-CEA F(ab')₂ fragment (empty symbols). Day 0 corresponds to tumor grafting and the arrow indicates the start of treatment on day one by injection of 20 µg conjugate i.v., followed by five repeated i.p. injections every four days. Tumor size was measured every two days with a caliper and expressed as a volume by the formula (length x width x height)/2. (A) Individual tumor growth curves for the five mice treated with conjugate and the five control mice over the first 25 days. (B) Means and standard deviations for the treated and control groups until the end of experiment when most control mice had tumors exceeding 1000 mm³. A Wilcoxon test performed on the day 28 data, when all the mice were still present, gave P = 0.0088 for the comparison between treated and control groups.