|
Combination
of immunization against OVA with CD40-activation does not protect
against E.G7 tumor growth.
|
Immunizationa
|
Antibodyb
|
Number
of Mice that Died from E.G7 Tumorc/ Number of
Immunized Mice
|
|
E.G7
|
CD40
|
5 / 8
|
|
Heat-denatured
OVA
|
CD40
|
7 / 7
|
|
E.G7
|
IgG2a
|
4 / 5
|
|
Heat-denatured
OVA
|
IgG2a
|
5 / 5
|
aC57BL/6 mice were immunized s.c. with 2 x 107
irradiated E.G7 cells or 1 mg heat-denatured OVA.
b100 µg of CD40-activating antibody FGK45 or
a rat IgG2a control antibody were given i.v. on days 0, 1 and
2.
cTwo weeks after immunization, mice were challenged
with 2.5 x 106 live E.G7 cells.
|
