|
SEREX-defined
breast cancer antigens: Antigens associated with autoimmune disease.
|
NY-BR-Antigen
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Identity
(Unigene Cluster)
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SEREX
Database ID Number1 of Equivalent Isolate
(TumorSource2)
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Autoimmune
Disease Associations3
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Reactivity
with
Normal Sera
|
Reactivity
with
Breast Cancer Sera
|
|
9
|
Ifn
inducible autoantigen 16 (Hs.155530)
|
|
SLE
|
1/12
|
1/10
|
|
12
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RNA
pol. II 23kDa subunit (Hs.24301)
|
|
SLE,
PSS
|
1/12
|
1/10
|
|
14
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Proteasome
activator subunit 3/ Ki nuclear autoantigen (Hs.152978)
|
|
SLE
|
1/12
|
1/10
|
|
28
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Glutathione
S-transferase theta –1 (Hs.77490)
|
|
AH
|
1/12
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2/10
|
|
31
|
Ribosomal
phosphoprotein P1 (Hs.177592)
|
|
SLE
|
5/25
|
2/25
|
|
39
|
DBI-related
protein (Hs.15250)
|
244
(RC), 1328 (GC), 1031(BC)
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AD
|
1/16
|
1/12
|
|
47
|
Dynamin
1-like protein (Hs.180628)
|
|
Sclero
|
0/20
|
1/20
|
|
58
|
Aldolase
A (Hs.273415)
|
79
(LC)
|
RA
|
0/20
|
1/20
|
|
59
|
PARP
(Hs.177766)
|
432
(CC), 698 (RC), 939 (BC)
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SLE,
SS, RA, PSS
|
1/18
|
1/20
|
|
64
|
Alanyl-tRNA
synthetase (Hs.75102)
|
471
(RC)
|
PM
|
0/20
|
1/20
|
|
65
|
Nuclear
matrix protein 238 (Hs.272822)
|
|
PM,
AH
|
0/20
|
1/20
|
|
69
|
Centromere
protein F (Hs.77204)
|
626
(PC), 1557 (EC), 809 (BC)
|
SLE,
Sclero
|
8/20
|
1/20
|
|
91
|
U1
snRNP (Hs.180789)
|
24
(GC), 349 (CC), 1267 (RC),
751
(BC)
|
SLE,
SS, RA, PM, Sclero
|
3/20
|
6/20
|
|
93
|
Human
autoantigen (Hs.75682)
|
|
SS,
SLE, Sclero, RA
|
0/20
|
1/20
|
|
97
|
Sjogren
syndrome antigen A1 (Hs.1042)
|
|
SS,
SLE
|
0/20
|
1/20
|
|
101
|
Vinculin
(Hs.75350)
|
1288
(BC)
|
thrombocytopenia
|
0/20
|
1/20
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1SEREX
database ID number from http://www.licr.org/SEREX.html.
2Tumor tissue abbreviations: BC, breast cancer; CC,
colon cancer; EC, esophageal cancer; GC, gastric cancer; LC, lung
cancer; , no additional isolates; PC, prostate cancer; RC, renal
cancer.
3Autoimmune disease abbreviations: AH, autoimmune hepatitis;
AD, autoimmune diabetes; PM, polymyositis; PSS, Progressive Systemic
Sclerosis; RA, Rheumatoid Arthritis; Sclero, scleroderma; SLE,
systemic lupus erythematosus; SS, Sjogren's Syndrome.
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