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Table 2

SEREX-defined breast cancer antigens: Reactivity with sera from normal individuals.

NY-BR-Antigen

Identity/Similarities

(Unigene cluster)

SEREX Database ID Number1 of Equivalent Isolate

(Tumor Source2)

Reactivity
with
Normal Sera

Reactivity
with
Breast Cancer Sera

Known Gene Products

8

H2K binding factor 2 (Hs.278573)

439 (RC), 1201 (MEL), 8 (GC)

1/16

2/10

13

Zuotin related factor 1 (Hs.82254)

6 (GC)

3/12

3/10

17

NP220 (Hs.169984)

1531 (OC)

1/12

2/10

22

Protein phosphatase 1B (Hs.5687)

 

1/12

1/10

23

DKFZp434L0117 (Hs.63795)

 

1/12

1/10

27

MHC Class I HLA Cw-0304 (Hs.277477)

 

4/25

2/25

29

Proteosome subunit p112 (Hs.3887)

 

6/12

4/10

30

GPDH (Hs.169476)

 

4/12

3/10

32

Ribosomal protein L34 (Hs.250895)

 

2/25

2/25

35

VEGFB (Hs.78781)

 

1/12

2/10

36

COL6A2 (Hs.4217)

 

4/19

6/20

42

Vacuolar sorting protein 45B (Hs. 6650)

 

1/17

1/25

43

Defender against cell death-1 (Hs.82890)

 

8/25

5/25

50

Sphingosine-1-phosphate lyase 1 (Hs.186613)

 

7/12

5/10

60

HIP-55 (Hs. 180766)

 

2/25

1/25

61

TGFB1 anti-apoptotic factor-1 (Hs.75822)

1057 (BC)

1/25

2/25

66

FBI-1 (Hs.104640)

 

1/20

2/20

68

Heme oxygenase 2 (Hs.63908)

 

2/20

2/20

70

KIAA0713 protein (Hs.88756)

159 (LC)

1/20

4/20

71

KIAA1002 protein (Hs.102483)

 

2/20

4/20

74

U2 snRNP auxiliary factor-2 (Hs.103962)

786 (HD), 430 (RC)

5/16

1/20

78

RNA helicase-related protein (Hs.8765)

 

3/25

1/25

80

TCP1 ring complex pp 5 (Hs.1708)

 

1/20

1/20

82

KIAA0801 protein (Hs.17585)

 

1/20

3/20

88

Talin (Hs.278559)

608 (PC)

1/20

1/20

89

Candidate of metastasis 1 (Hs.8603)

 

1/20

1/20

90

NAP-22 (Hs.79516)

 

1/20

2/20

95

KIAA0376 protein (Hs.4791)

1777 (CC), 357 (RC), 551 (GC), 955 (BC)

11/20

11/20

100

BRACA-1 AP 2 (Hs.122764)

1785 (CC), 1158 (RC), 190 (PC), 1616 (OC), 807 (BC)

2/19

2/20

Novel Gene Products

15

Putative nuclear protein (Hs.178175)

 

1/12

1/10

16

Similar to Ankyrin (Hs.190251)

1792 (CC)

4/12

6/10

18

RNA splicing factor similarity (Hs.11065)

 

2/12

1/10

20

Similar to calmodulin (Hs.239812)

 

1/12

1/10

24

Similar to CDC 10 proteins (Hs.99741)

 

1/12

1/10

40

None (Hs.149190)

 

1/12

2/10

81

Phospholipase C beta similarity (Hs.75280)

 

1/20

1/20

86

Oxysterol binding protein similarity (Hs.233495)

319 (GC)

2/17

2/20

87

2 possible reading frames (Hs.18946)

 

1/25

1/25

1 SEREX database ID number from http://www.licr.org/SEREX.html.
2 Abbreviations: BC, breast cancer; CC, colon cancer; HD, Hodgkins disease; GC, gastric cancer; LC, lung cancer; MEL, melanoma; OC, ovarian cancer; PC, prostate cancer; RC, renal cancer

 

Copyright © 2001 by Matthew J. Scanlan