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Table 1

Immunoscreening of cDNA expression libraries from breast cancer with autologous and allogeneic patient sera (SEREX).

Tumor Type

Serum Source

Breast Cancer cDNA Library Designation

Number of Distinct Antigens Identified by SEREX

(Known1/Novel2)

Antigens with Non-Cancer Related Serological Profiles

Antigens with Cancer-related Serological Profiles

Invasive ductal carcinoma

Autologous

184

17 (12/5)

13

4

Invasive ductal carcinoma

Autologous

297

6 (6/0)

5

1

Invasive ductal carcinoma

Autologous

257

9 (8/1)

4

5

Invasive pleomorphic lobular carcinoma

Autologous

263

13 (9/4)

5

8

SK-BR-3 (established breast cancer cell line)

Allogeneic-1

9993

34 (27/7)

14

20

SK-BR-3

Allogeneic-2

9993

15 (12/3)

9

6

Totals

94 (74/20)

50

44

1Identical to GenBank Entries.
2Identities limited to expressed sequence tags (ESTs).

 

Copyright © 2001 by Matthew J. Scanlan