 |
Updated:
October 23, 2007
|
Table
2. Shared tumor-specific antigens
| Gene |
HLAa |
HLA
Frequencyb
(%) |
Peptide |
Position |
Lymphocyte
Stimulation Method |
References |
|
BAGE-1 |
Cw16 |
7 |
AARAVFLAL |
2-10 |
autologous
tumor cells |
Boel, 1995
|
|
GAGE-1,2,8 |
Cw6 |
18 |
YRPRPRRY |
9-16 |
autologous
tumor cells |
Van den Eynde, 1995 |
|
GAGE-3,4,5,6,7 |
A29 |
6 |
YYWPRPRRY |
10-18 |
autologous
tumor cells |
De Backer, 1999 |
|
GnTVf |
A2 |
44 |
VLPDVFIRC(V) |
intron |
autologous
tumor cells |
Guilloux, 1996 |
| HERV-K-MEL |
A2 |
44 |
MLAVISCAV |
1-9 |
autologous
tumor cells |
Schiavetti, 2002 |
|
KK-LC-1 |
B15 |
13 |
RQKRILVNL |
76-84 |
autologous
tumor cells |
Fukuyama, 2006 |
KM-HN-1
|
A24 |
20 |
NYNNFYRFL |
196-204 |
peptide |
Monji, 2004 |
| A24 |
20 |
EYSKECLKEF |
499-508 |
peptide |
Monji, 2004 |
| A24 |
20 |
EYLSLSDKI |
770-778 |
peptide |
Monji, 2004 |
|
LAGE-1 |
A2 |
44 |
MLMAQEALAFL |
ORF2
(1-11) |
autologous
tumor cells |
Aarnoudse, 1999 |
| A2 |
44 |
SLLMWITQC |
157-165 |
peptide |
Rimoldi, 2000 |
| A31 |
5 |
LAAQERRVPR |
ORF2
(18-27) |
autologous
tumor cells |
Wang, 1998 |
| A68 |
8 |
ELVRRILSR |
103-111 |
adenovirus-dendritic
cells |
Sun, 2006 |
| B7 |
17 |
APRGVRMAV |
ORF2
( 46-54) |
adenovirus-APC |
Slager, 2004b |
| DP4 |
75 |
SLLMWITQCFLPVF |
157-170 |
peptide |
Zeng, 2001 |
| DR3 |
21 |
QGAMLAAQERRVPRAAEVPR |
ORF2
(14-33) |
protein |
Slager, 2004a
|
| DR4 |
24 |
AADHRQLQLSISSCLQQL |
139-156 |
protein |
Jager, 2000 |
| DR11 |
25 |
CLSRRPWKRSWSAGSCPGMPHL |
ORF2
(81-102) |
peptide |
Slager, 2003 |
| DR12 |
5 |
CLSRRPWKRSWSAGSCPGMPHL |
ORF2
(81-102) |
peptide |
Slager, 2003 |
| DR13 |
19 |
ILSRDAAPLPRPG |
108-120 |
autologous
tumor cells |
Wang, 2004 |
| DR15
 |
20 |
AGATGGRGPRGAGA |
37-50 |
protein |
Hasegawa, 2006 |
|
MAGE-A1 |
A1 |
26 |
EADPTGHSY |
161-169 |
autologous
tumor cells |
Traversari, 1992 |
| A2 |
44 |
KVLEYVIKV |
278-286 |
peptide |
Ottaviani, 2005
Pascolo, 2001 |
| A3 |
22 |
SLFRAVITK |
96-104 |
poxvirus-dendritic
cellsc |
Chaux, 1999a |
| A68 |
8 |
EVYDGREHSA |
222-231 |
poxvirus-dendritic
cells |
Chaux, 1999a
|
| B7 |
17 |
RVRFFFPSL |
289-298 |
poxvirus-dendritic
cells |
Luiten, 2000a |
| B35 |
20 |
EADPTGHSY |
161-169 |
poxvirus-dendritic
cells |
Luiten, 2000b |
| B37 |
3 |
REPVTKAEML |
127-136 |
autologous
tumor cells |
Tanzarella, 1999 |
| B53 |
2 |
DPARYEFLW |
258-266 |
poxvirus-dendritic
cells |
Chaux, 1999a
|
| B57 |
8 |
ITKKVADLVGF |
102-112 |
ALVAC-dendritic
cells |
Corbière, 2004
|
| Cw2 |
10 |
SAFPTTINF |
62-70 |
poxvirus-dendritic
cells |
Chaux, 1999a
|
| Cw3 |
17 |
SAYGEPRKL |
230-238 |
poxvirus-dendritic
cells |
Chaux, 1999a
|
| Cw16 |
7 |
SAYGEPRKL |
230-238 |
autologous
tumor cells |
van der Bruggen, 1994a |
| DP4
|
75 |
TSCILESLFRAVITK |
90-104 |
peptide |
Wang, 2007 |
| DP4
|
75 |
PRALAETSYVKVLEY |
268-282 |
peptide |
Wang, 2007 |
| DR13 |
19 |
LLKYRAREPVTKAE |
114-127 |
protein |
Chaux, 1999b |
| DR15 |
20 |
EYVIKVSARVRF |
281-292 |
protein |
Chaux, 2001 |
|
MAGE-A2 |
A2 |
44 |
YLQLVFGIEV |
157-166 |
peptide |
Kawashima, 1998 |
| A24 |
20 |
EYLQLVFGI |
156-164 |
peptide |
Tahara, 1999 |
| B37 |
3 |
REPVTKAEML |
127-136 |
autologous
tumor cells |
Tanzarella, 1999 |
| Cw7 |
41 |
EGDCAPEEK |
212-220 |
lentivirus-dendritic
cells |
Breckpot, 2004 |
| DR13 |
19 |
LLKYRAREPVTKAE |
121-134 |
protein |
Chaux, 1999b |
|
MAGE-A3 |
A1 |
26 |
EVDPIGHLY |
168-176 |
autologous
tumor cells |
Gaugler, 1994 |
| A2 |
44 |
FLWGPRALVd |
271-279 |
peptide |
van der Bruggen, 1994b |
| A2 |
44 |
KVAELVHFL |
112-120 |
peptide |
Kawashima, 1998 |
| A24 |
20 |
TFPDLESEF |
97-105 |
peptide |
Oiso, 1999 |
|
A24 |
20 |
VAELVHFLL |
113-121 |
peptide |
Miyagawa, 2006 |
| B18 |
6 |
MEVDPIGHLY |
167-176 |
adeno-dendritic
cells |
Bilsborough, 2002 |
| B35 |
20 |
EVDPIGHLY |
168-176 |
poxvirus-dendritic
cells |
Schultz, 2001 |
| B37 |
3 |
REPVTKAEML |
127-136 |
autologous
tumor cells |
Tanzarella, 1999 |
| B40 |
6 |
AELVHFLLLi |
114-122 |
adeno-dendritic
cells |
Schultz, 2002 |
| B44 |
21 |
MEVDPIGHLY |
167-176 |
peptide |
Herman, 1996
|
| B52 |
5 |
WQYFFPVIF |
143-151 |
retrovirus-dendritic
cellsh |
Russo, 2000
|
| Cw7 |
41 |
EGDCAPEEK |
212-220 |
lentivirus-dendritic
cells |
Breckpot, 2004 |
| DP4 |
75 |
KKLLTQHFVQENYLEY |
243-258 |
protein |
Schultz, 2000 |
| DQ6 |
63 |
KKLLTQHFVQENYLEY |
243-258 |
peptide |
Schultz, 2004 |
| DR1 |
18 |
ACYEFLWGPRALVETS |
267-282 |
protein |
Zhang, 2003 |
| DR4 |
24 |
VIFSKASSSLQL |
149-160 |
peptide |
Kobayashi, 2001 |
| DR7 |
25 |
VIFSKASSSLQL |
149-160 |
peptide |
Kobayashi, 2001 |
| DR11 |
25 |
GDNQIMPKAGLLIIV |
191-205 |
peptide |
Consogno, 2003 |
| DR11 |
25 |
TSYVKVLHHMVKISG |
281-295 |
protein |
Manici, 1999 |
| DR13 |
19 |
AELVHFLLLKYRAR |
114-127 |
protein |
Chaux, 1999b |
| DR13 |
19 |
LLKYRAREPVTKAE |
121-134 |
protein |
Chaux, 1999b |
|
MAGE-A4 |
A1 |
26 |
EVDPASNTYj |
169-177 |
peptide
after tetramer sorting |
Kobayashi, 2003 |
| A2 |
44 |
GVYDGREHTV |
230-239 |
adeno-dendritic
cells |
Duffour, 1999 |
| A24 |
20 |
NYKRCFPVI |
143-151 |
peptide |
Miyahara, 2005
Ottaviani, 2006 |
| B37 |
3 |
SESLKMIF |
156-163 |
poxvirus-dendritic
cells |
Zhang, 2002 |
|
MAGE-A6 |
A34 |
1 |
MVKISGGPR |
290-298 |
autologous
tumor cells |
Zorn, 1999 |
| B35 |
20 |
EVDPIGHVY |
168-176 |
autologous
tumor cells |
Benlalam, 2003 |
| B37 |
3 |
REPVTKAEML |
127-136 |
autologous
tumor cells |
Tanzarella, 1999 |
| Cw7 |
41 |
EGDCAPEEK |
212-220 |
lentivirus-dendritic
cells |
Breckpot, 2004 |
| Cw16 |
7 |
ISGGPRISY |
293-301 |
autologous
tumor cells |
Vantomme, 2003 |
| DR13 |
19 |
LLKYRAREPVTKAE |
121-134 |
protein |
Chaux, 1999b |
| MAGE-A9 |
A2 |
44 |
ALSVMGVYV |
223-231 |
peptide |
Oehlrich, 2005 |
|
MAGE-A10 |
A2 |
44 |
GLYDGMEHL |
254-262 |
autologous
tumor cells |
Huang, 1999 |
| B53 |
2 |
DPARYEFLW |
290-298 |
poxvirus-dendritic
cells |
Chaux, 1999a
|
|
MAGE-A12 |
A2g |
44 |
FLWGPRALVe |
271-279 |
peptide |
van der Bruggen, 1994b |
| Cw7 |
41 |
VRIGHLYIL |
170-178 |
autologous
tumor cells |
Heidecker, 2000
Panelli, 2000 |
| Cw7 |
41 |
EGDCAPEEK |
212-220 |
lentivirus-dendritic
cells |
Breckpot, 2004 |
| DP4
|
75 |
REPFTKAEMLGSVIR |
127-141 |
peptide |
Wang, 2007 |
| DR13 |
19 |
AELVHFLLLKYRAR |
114-127 |
protein |
Chaux, 1999b |
|
MAGE-C2 |
A2 |
44 |
LLFGLALIEV |
191-200 |
autologous
tumor cells |
Ma, 2004 |
| A2 |
44 |
ALKDVEERV |
336-344 |
autologous
tumor cells |
Ma, 2004 |
| B44
|
21 |
SESIKKKVL |
307-315 |
autologous
tumor cells |
Godelaine, 2007 |
mucin
k |
|
|
PDTRPAPGSTAPPAHGVTSA |
|
transfected
B cells |
Jerome, 1993 |
|
NA-88 |
B13 |
6 |
QGQHFLQKV |
|
autologous
tumor cells |
Moreau-Aubry, 2000 |
|
NY-ESO-1
/ LAGE-2 |
A2 |
44 |
SLLMWITQC |
157-165 |
autologous
tumor cells |
Jager, 1998
Chen, 2000
Valmori, 2000
|
| A2 |
44 |
MLMAQEALAFL |
ORF2
(1-11) |
autologous
tumor cells |
Aarnoudse, 1999 |
| A31 |
5 |
ASGPGGGAPR |
53-62 |
autologous
tumor cells |
Wang, 1998 |
| A31 |
5 |
LAAQERRVPR |
ORF2
(18-27) |
autologous
tumor cells |
Wang, 1998 |
| B35 |
20 |
MPFATPMEA |
94-102 |
autologous
tumor cells |
Benlalam, 2003 |
| B51 |
12 |
MPFATPMEA |
94-102 |
adenovirus-APC |
Jäger, 2002 |
| Cw3 |
17 |
LAMPFATPM |
92-100 |
adenovirus-PBMC |
Gnjatic, 2000 |
| Cw6 |
18 |
ARGPESRLL |
80-88 |
adenovirus-PBMCd |
Gnjatic, 2000 |
| DP4 |
75 |
SLLMWITQCFLPVF |
157-170 |
peptide |
Zeng, 2001 |
| DP4 |
75 |
LLEFYLAMPFATPMEAELARRSLAQ |
87-111 |
peptide |
Mandic, 2005 |
| DR1 |
18 |
LLEFYLAMPFATPMEAELARRSLAQ |
87-111 |
peptide |
Mandic, 2005 |
| DR1 |
18 |
EFYLAMPFATPM |
89-100 |
protein |
Chen, 2004
|
| DR2 |
25 |
RLLEFYLAMPFA |
86-97 |
protein |
Chen, 2004
|
| DR3 |
21 |
QGAMLAAQERRVPRAAEVPR |
ORF2
(14-33) |
protein |
Slager, 2004a
|
| DR4 |
24 |
PGVLLKEFTVSGNILTIRLT |
119-138 |
peptide
and protein |
Jager, 2000
Zarour, 2000 |
| DR4 |
24 |
VLLKEFTVSG |
121-130 |
peptide |
Zeng, 2000 |
| DR4 |
24 |
AADHRQLQLSISSCLQQL |
139-156 |
protein |
Jager, 2000 |
| DR4 |
24 |
LLEFYLAMPFATPMEAELARRSLAQ |
87-111 |
peptide |
Mandic, 2005 |
| DR7 |
25 |
PGVLLKEFTVSGNILTIRLTAADHR |
119-143 |
peptide |
Zarour, 2002 |
| DR7
|
25 |
LLEFYLAMPFATPMEAELARRSLAQ |
87-111 |
peptide |
Mandic, 2005 |
| DR15 |
20 |
AGATGGRGPRGAGA |
37-50 |
protein |
Hasegawa, 2006 |
|
SAGE |
A24 |
20 |
LYATVIHDI |
715-723 |
peptide |
Miyahara, 2005 |
|
Sp17 |
A1 |
26 |
ILDSSEEDK |
103-111 |
protein |
Chiriva-Internati, 2003 |
|
SSX-2 |
A2 |
44< | | |
