Table 2. Shared tumor-specific antigens

^aClass II HLA are indicated in blue.
^bFrequency in Caucasians, based on (1) Marsh SGE, Parham P, Barber LD. The HLA Factsbook (Academic Press, 2000) for HLA-A, B, C, and DR, and (2) Colombani J. HLA, Fonctions immunitaires et applications médicales (John Libbey Eurotext, 1993) for HLA-DP and DR.
^cALVAC recombinant poxvirus carrying the entire gene were used to infect dendritic cells.
^dOnly processed by the intermediate proteasome β5i (Guillaume, 2010).
^eSame peptide as MAGE-A3/A2 (aa 271-279).
^fAberrant transcript of N-acetyl glucosaminyl transferase V (GnTV) that is found only in melanomas.
^gIncompletely spliced transcript found only in melanomas.
^hRetrovirus carrying the entire gene were used to infect dendritic cells.
ⁱThe processing of this peptide requires the immunoproteasome.
^jThis peptide is encoded by allele MAGE-4a, which is expressed in one third of MAGE-4 positive tumor samples. The other allele, namely MAGE-4b, encodes peptide EVDPTSNTY.
^kMHC-unrestricted recognition by CTL of a repeated motif that is unmasked in tumors due to mucin underglycosylation. Mucin underglycosylation also occurs in breast duct epithelial cells during lactation, but only at the extracellular apical surface, which is not accessible to T cells.
^lOnly processed by the intermediate proteasome β1iβ51 (Guillaume, 2010).

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