|
Characteristics
of cancer/testis antigens with known immunogenicity in humans.
|
Gene/Gene
Family
|
No.
of Genes
|
Chromosome
|
CTL
Recognition
|
Ab
Recognition
|
References
|
|
MAGE-A
|
11
|
Xq28
|
+
|
+
|
19,
67,
85
|
|
BAGE
|
5
|
13
and 21
|
+
|
+a
|
67,
150
|
|
GAGE
|
8
|
Xp11.4-p11.2
|
+
|
Unknown
|
67
|
|
SSX
|
9
|
Xp11.23-p11.22
|
+
|
+
|
22,
67,
85,
145,
146
|
|
NY-ESO-1/LAGE-1
|
3b
|
Xq28
|
+
|
+
|
28,
41,
85,
86
|
|
SCP1
|
1
|
1p13-p12
|
Unknown
|
+
|
23
|
|
CT7/MAGE-C1
|
1
|
Xq26
|
Unknown
|
+
|
25,
68
|
|
CT8/HOM-TES-85
|
1
|
Xq24
|
Unknown
|
+
|
24
|
|
CT10
|
1
|
Xq27
|
Unknown
|
+
|
27,
106
|
|
CAGE
|
1
|
Xp22
|
Unknown
|
+
|
147
|
|
CAGE-1
|
1
|
6p24
|
Unknown
|
+
|
96
|
|
cTAGE1
|
5
|
18p11
|
Unknown
|
+
|
124
|
|
XAGE-1
|
5
|
Xp11
|
Unknown
|
+
|
97,
104
|
|
ACRBP/OY-TES-1
|
1
|
12p13
|
Unknown
|
+
|
133
|
aCancer
Immunome Database (150),
clone HOM-TS-GLI-38.
bOf the 3 family members, NY-ESO-1 and LAGE-1 are CT
antigens, while the third member (ESO3) is ubiquitously expressed.
|
