Cancer/Testis (CT) Gene Database
Cancer/testis genes encode a heterogeneous
group of immunogenic proteins (CT antigens) expressed
almost exclusively in normal testis and a percentage of
various tumor types. On the basis of their tissue specificity
and immunogenicity, CT antigens are considered some of
the more promising target molecules for cancer vaccines.
The CT Gene Database provides information
about gene structure, chromosomal mapping, proteins, immunoreactivity
in cancer patients and mRNA expression through a set of
interlinked web pages as well as external links to public
databases such as the NCBI, Ensembl, SwissProt, Cancer
Immunome Database (CID) or LICR Transcriptome database.
The growing list of CT transcript families necessitates
the adoption of a standardized nomenclature for these
gene products. The CT Gene Database presents a possible
nomenclature.
The content of the CT Gene Database has
been compiled by Matthew J. Scanlan of the LICR New York
Branch at the Memorial Sloan-Kettering Cancer Center,
and Yves Stauffer, Gregory Theiler, Monique Zahn
and Victor Jongeneel of the Office of Information Technology,
LICR Lausanne Branch. It is based on published reports.
